Secreted by the adrenal glands, cortisol induces the “fight or flight” response that helps to keep you alert in high-stress situations. However, in the long term, high cortisol levels, stimulated by stress, can have dire consequences for health. That’s why we’re here to review the best cortisol supplements for you.

Unfortunately, in today’s fast-paced world, stressors have become almost unavoidable. There are constant work demands, family pressures, and countless daily hassles, such as traffic jams or financial obligations.

We, humans, are often overworked, overwhelmed, and overstimulated in this day and age. As a result, many of us may be carrying chronically excessive cortisol levels and possibly not even know it.

High cortisol levels can contribute to:

Persistent Fatigue & Tiredness

“Junk Food” Cravings

Increased Body Fat

Reduced Muscle Mass & Strength

Difficulty Focusing & Being Productive

Lowered Motivation

Erratic Thoughts 

Hormonal Disparities

An overabundance of cortisol could also damage sleep quality, bring about mood swings, and sabotage sexual wellness.

Do any of these potential indicators of high cortisol level sound familiar to you?

If so, the best cortisol supplements could help you improve your overall quality of life by promoting optimal hormonal balance. In this article, we’ll provide you with a bit of insight into precisely what cortisol is, and we’ll break down the best cortisol supplements on the market right now.

The Best Cortisol Supplements—Our Top 5

We’ve searched high and low for the best cortisol supplements available. After much thought and deliberation, our list was narrowed down to 5 elite all-natural products.

These supplements require no prescription but could help to naturally lower cortisol levels with consistent usage.

The best cortisol supplements are:

1 CortiSync—Best Overall Product & Best Results

2 Xanapril—Best For Helping To Reduce Anxiousness 

3 Nooceptin—Best For Supporting Lessened Brain Fog

4 Vyvamind—Best For Stimulating Mental Stamina

5 Noocube—Best For Improving Attention Span

In compiling this list, we considered factors like ingredient quality, research support, user reviews, manufacturing practices, money-back guarantees, and affordability.

Based on that, it became evident that CortiSync by PrimeGENIX is the clear-cut #1 all-natural cortisol support supplement money can buy. This vegetarian, plant-based, Non-GMO formula is an elite class all by itself.

What Is Cortisol & How Does It Affect You Exactly?

Cortisol is the preeminent stress response hormone. Whenever you feel pressured or threatened, the brain sends biochemical signals to the adrenal glands, ordering them to produce more cortisol. In the short term, elevated cortisol levels can help you to be mentally sharper and even physically stronger.

Our ancestors needed this stress response system to run away from predators or fight their enemies. However, nowadays, our stress response can be triggered by many common daily occurrences, such as a looming work deadline or an overly noisy barking dog.

A 2018 study including 107 healthy students aged 19-23 determined participants’ cortisol levels rose by 900&#37 on average during “stressful periods” such as the time leading up to an exam.[1]

And a clinical review carried out by researchers at the University of Florida noted that human cortisol levels could rise significantly even from just anticipating future stress.[2]

Studies like these suggest that in today’s technology-driven, fast-paced world, many of us could be dealing with cortisol spikes that simply weren’t occurring in former generations when life moved slower.

In small amounts, cortisol helps to:

Maximize Energy Metabolism

Increase Pain Threshold

Lower Inflammation

Enhance Blood Flow

Boost Muscle Endurance

The problem is when cortisol is regularly being produced day after day, “burnout” can occur. This is when the “stress hormone” may transform from being a beneficial compound into being harmful to many aspects of health and wellness.

Some lifestyle changes like healthy dietary practices, regular strenuous exercise, and avoiding stressful situations can help to reduce cortisol levels in time.

However, the best cortisol supplements are formulated to reduce cortisol production organically without necessitating lifestyle changes. Now, we’ll give you all the pertinent information on how these 100&#37 natural dietary aids work.

1 CortiSync—Best Overall & Best Results

CortiSync, an American-made product, takes the cake as the best cortisol supplement overall. This no-nonsense formula is jam-packed with all-natural, high-quality adaptogens (natural compounds that can help the body reduce stress).

Built by PrimeGENIX, a well-respected health supplement company with over 20 years of success building elite supplements, CortiSync brings some serious power to the table. And it has no reported negative side effects.

If you’re looking to incorporate an all-natural cortisol supplement into your routine, we believe CortiSync is the best choice. It requires taking just 2 small pills daily and could deliver benefits in 4-6 weeks on average.


The CortiSync ingredient list is organic and vegetarian-friendly. It contains 7 natural adaptogens, several of which have a long history of use in Ayurvedic therapeutics and have modern research support.

CortiSync’s primary ingredients are:

Sensoril (Purified Ashwagandha Extract)

Holy Basil


Lemon Balm




This polyherbal formula combines what are likely some of the best cortisol-resistant adaptogens known to humankind. It contains no chemical additives and no preservatives but could deliver massive results.

Sensoril is a patented extract of the Ashwagandha plant. The extract contains high concentrations of beneficial bioactive compounds from the herb’s roots and leaves.

A study at Asha Hospital in Hyderabad, including 64 participants, concluded that supplementing with purified Ashwagandha extract decreased levels of stress in 60 days, as measured by a standardized stress assessment.[3]

Another key ingredient, L-Theanine, is highly concentrated in some tea leaves. A Japanese study of 69 healthy adults noted that supplementing with L-Theanine promoted enhanced cognitive wellness, including boosted attention and strengthened memory, after 12 weeks.[4]

It’s evident that CortiSync employs an elite mixture of well-established adaptogens, which, when combined, could yield enormous results for cortisol reduction.

Money-Back Guarantee

CortiSync comes with a 67-day money-back guarantee. You can even buy the supplement, use it, and return it for a refund of the purchase price.

You’ll receive a refund for all used and unused packaging.

This elite money-back guarantee provides excellent peace of mind for users. It shows the manufacturer has absolute confidence in their product.


A single bottle, or 1-month supply, of Cortisync, costs $59.95. And when you buy in bulk, you’ll save some money.

Pricing packages look like this:

3-Month Supply—$56.65 per bottle

6-Month Supply—$53.33 per bottle

These prices offer great bang for the buck. In fact, CortiSync is priced lower than most of its competitors. Shipping is fast and discreet. And the manufacturer provides free shipping in the continental USA.

Where To Purchase

Go directly to the official CortiSync webpage for the best prices, excellent customer service, and the money-back guarantee.

2 Xanapril—Best For Helping To Reduce Anxiousness 

The second among the best cortisol supplements is Xanapril. Designed to help reduce anxiousness and reduce stress, Xanapril has garnered a solid reputation for providing reliable results.

User reviews suggest the all-natural supplement may help boost daily moods and improve emotional management without any reported negative side effects.

If you struggle with bouts of extreme anxiousness or uneasiness regularly, Xanapril could be a good option for you. 


Xanapril uses a blend of 5 all-natural compounds, some of which might benefit cortisol levels and reduce stress. Compounds like Ashwagandha and Korean Red Ginseng generally indicate a good all-natural supplement.

The primary ingredients are:

Magnesium L-Threonate


Gamma-Aminobutyric Acid

Korean Ginseng Extract

Rhodiola Rosea Extract

This ingredient list is adequate for promoting several aspects of wellness, including the support of cortisol mitigation. It doesn’t use any harmful additives but could promote reduced anxiousness.

Korean Ginseng, or Panax Ginseng, has a storied history in the therapeutic practices of northeast Asia.

A study in Beijing, China, concluded that extracts of Panax Ginseng could help stimulate the release of neurotransmitters in the brain.[5] Adequate neurotransmitter release is vital to moods and mental wellness.

It’s clear that Xanapril uses legitimate ingredients to help achieve adaptogenic effects and reduce cortisol levels.

Money-Back Guarantee

Xanapril doesn’t appear to come with a money-back guarantee at this time.

Generally speaking, we think the best cortisol supplements should provide money-back guarantees as a form of consumer protection.

However, Xanapril, despite having a solid overall foundation as a product, doesn’t offer any form of refund.


A 1-month supply of Xanapril costs $69.00. Buying multiple bottles at a time can provide some savings.

While Xanapril offers bulk discounts, you`re risking your hard-earned cash if the supplement doesn`t give you the results you`re looking for since there is no money-back guarantee.

Where To Purchase

Head to the official Xanapril homepage to find this product`s lowest prices and best customer service.

3 Nooceptin—Best For Supporting Lessened Brain Fog

Third on our list of the best cortisol supplements is the all-natural formula, Nooceptin. Designed with adaptogens to reduce cortisol levels and other compounds that could support cognitive improvements, Nooceptin is a good choice for people with daily brain fog issues.

Requiring just 2 capsules a day and offering no known negative side effects, Nooceptin could help many focus longer and be more productive while reducing stress.

If you need to think clearer and focus better throughout your day, Nooceptin might be right for you.


Nooceptin contains a combination of 7 all-natural ingredients. The mixture of adaptogens and beneficial herbal extracts may provide several benefits for users.

The primary ingredients are:


Rhodiola Rosea

Bacopa Monnieri Extract


Ginkgo Biloba Extract

Lion’s Mane Extract

Panax Ginseng Extract

You’ll notice Nooceptin shares some ingredients in common with the other best cortisol supplements. Several high-quality compounds like L-Theanine, Rhodiola Rosea, and Panax Ginseng help to promote beneficial outcomes for users.

Rhodiola Rosea, sometimes called Arctic Root or Golden Root, is a plant with potent adaptogenic and stress-reducing components.

A 2022 clinical review published in Molecules stated Rhodiola Rosea “is able to enhance the body’s non-specific resilience to physical and mental stresses and normalize its functions”.[6]

The diverse group of adaptogens in Nooceptin makes for a high-quality ingredient list that could yield solid results for users.

Money-Back Guarantee

Nooceptin doesn’t provide a money-back guarantee at this time.

It would be reassuring to see a money-back guarantee associated with this product.

However, the reliable list of adaptogens indicates that Nooceptin is at least a good supplement for reducing cortisol.


A 1-month supply of Nooceptin costs $69.00. Buying multiple months’ worth of the product may offer some savings.

Nooceptin does offer fast and tracked shipping in most locations using discreet packaging.

Where To Purchase

You’ll want to get Nooceptin from the supplement’s official homepage to get the best deals and customer service.

4 Vyvamind—Best For Stimulating Mental Stamina

Vyvamind is a 100&#37 natural supplement designed to stimulate increased mental stamina. It ranks fourth on our list of the best cortisol supplements because of its high-quality ingredient list, containing several reliable compounds.

With just 2 capsules a day, this product could help users to focus and perform better mentally. This ability could be critical for individuals working in a fast-paced, highly-demanding environment.

If you require a natural way to kickstart your mental stamina, Vyvamind is an option. However, we should note, Vyvamin does contain a natural, dehydrated form of caffeine.


Vyvamind is formulated using 6 all-natural ingredients. This concoction of vitamins, amino acids, and natural stimulants may help you operate at peak capacity for elongated periods.

The primary ingredients are:

Vitamin B6

Vitamin B12




Caffeine Anhydrous

The unique ingredient list behind Vyvamind is solid. The presence of vitamins and amino acids suggests it could have multiple rewards that help users to perform better under pressure.

L-Tyrosine is a non-essential amino acid highly concentrated in some foods like meat, eggs, and dairy products. It’s sometimes used as a supplement to boost mental performance.

A small study involving soccer players concluded that supplementing with L-Tyrosine improved the participants’ vigilance during times of high stress and high heat.[7] L-Tyrosine is also a precursor to dopamine, a vital neurotransmitter.

It’s easy to like the Vyvamin formula. However, it would be nice to see some critical adaptogens like Ashwagandha included.

Money-Back Guarantee

Vyvamind provides a 30-day money-back guarantee, but they don’t cover any used or opened packaging.

So, you won’t be getting a “free test drive” with this product. But, in most cases, you’ll be refunded for the purchase price of any unused product.


A 1-month supply of Vyvamind costs $74.99. Buying in bulk can save you some money.

Pricing packages look like this:

2-Month Supply—$69.99 per bottle

3-Month Supply—$69.00 per bottle

Vyvamind is slightly above the average price of its competitors. However, the manufacturer provides solid savings when you order a few bottles.

Where To Purchase

We’d recommend buying directly from the Vyvamind official homepage to get the best price and the money-back guarantee.

5 Noocube—Best For Improving Attention Span

Next up is the fifth-best cortisol supplement, Noocube. Made to help reduce stress and enhance attention span, Noocube has earned a reputation for reliability in recent years. The 100&#37 natural formula has multiple impressive components.

If you, like so many others, struggle with a short attention span, potentially brought about by stress, Noocube may be good for you.


Noocube contains a variety of all-natural compounds. It employs 13 individual ingredients ranging from adaptogens to amino acids.

The primary ingredients are:

Lutemax 2020 (Proprietary Marigold Extract)

Bacopa Monnieri

Huperzia Serrata





Alpha GPC

Oat Straw Extract

Cat’s Claw Extract

Vitamin B1

Vitamin B7

Vitamin B12

The diverse Noocube ingredient list is something to behold. Many of the compounds could help to stimulate multiple benefits for users.

Lutemax 2020, a proprietary compound extracted from Marigold, is the most critical component.

A study by researchers at the University of Georgia (USA) concluded that supplementing with the bioactive compounds in Lutemax 2020 effectively improved cognitive wellness in young adults.[8]

Many ingredients in Noocube could help to provide several benefits for users.

Money-Back Guarantee

Noocube comes with a 60-day money-back guarantee. They will refund you for the purchase price of any used or unused supplements.

This is a good money-back guarantee, providing reliable protection for users.


A 1-month supply of Noocube costs $64.99.

When you order 2 months’ worth, you get the third free. And when you order 3 months’ worth, you get 2 more free.

Noocube is competitively priced with good bulk order savings.

Where To Purchase

The best place to get Noocube is through the supplement’s official homepage.

Best Cortisol Supplements—Final Thoughts

Stress is everywhere these days. With the advent of modern technology like smartphones and smartwatches, it can become inescapable.

As a result, many of us may be accumulating cortisol levels that are growing far too high. This increase in the “stress hormone” may make us feel more fatigued, less motivated, and like a shell of our former selves.

The best cortisol supplements could help. CortiSync is our pick as the best overall product. It’s absolutely worth a look for most people who may want help to reduce signs of chronic stress.

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