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Focus on Your Feet! | NIH News in Health

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March 2023






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Take Steps to Protect Foot Health

Most of us go through each day without ever thinking about our feet. It’s only when something goes wrong that we tend to realize just how important our feet really are.

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“Our feet are usually covered with shoes and socks, and they’re easy to forget about, or we might take them for granted,” says Dr. David G. Armstrong, a foot doctor (podiatrist) and professor of surgery at the University of Southern California. “But we shouldn’t ignore them. Foot problems can really limit activity and make it hard to move through the world.”

Your feet are surprisingly complex. Each foot has 26 bones, 33 joints, and a network of nerves and blood vessels. Your feet also have more than 100 muscles and connectors, called tendons and ligaments.

“All of these work together to give your whole body stability and balance as you move around every day,” says Dr. Stephanie C. Wu, a podiatrist at Rosalind Franklin University in Chicago. “Our lowly feet have big responsibilities.”

You can help your hard-working feet stay at their best. Start by being alert to foot pain or other problems that might need a doctor’s care.

Pay Attention to Problems

The foot’s complexity means there’s a lot that can go wrong. “Foot problems can range from annoying to devastating,” says Dr. Crystal M. Holmes, who heads the podiatry program at Michigan Medicine. “You can have skin problems like athlete’s foot, which is caused by fungus. Or you can have warts, which is a viral infection. These generally are not serious. But certain other skin infections can wreak havoc if left untreated.”

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You can also get painful structural problems, like bunions or hammertoes. A hammertoe is a stiff bend in a toe’s middle joint. It can be caused by stubbing your toe or wearing shoes that are too tight. A bunion is a bony bump, usually on the outer side of the big toe. Bunions tend to run in families. Both conditions can first be treated by wearing shoes with plenty of toe room. Eventually, surgery may be needed.

Other common foot problems include sports injuries, toenail troubles, and painful joints. A condition called plantar fasciitis causes sharp heel pain that declines throughout the day. Many people with plantar fasciitis recover in a few months, in part by avoiding the activities that cause pain. If the pain lasts longer, medical treatment may be needed.

Your feet can also provide early clues to problems in other parts of your body. For example, stiff joints in your feet or ankles could be a sign of arthritis elsewhere. Swollen feet could warn of high blood pressure or kidney or heart disease. Tingling, burning, or numbness might signal some type of nerve damage. And nerve damage in the foot is often a warning sign of diabetes.

Foot Health and Diabetes

People who have diabetes need to pay special attention to their feet. Diabetes affects about one in 10 Americans. Most people with diabetes—about 60% to 70%—develop nerve problems. These can range from mild to severe. Diabetic nerve damage, or diabetic neuropathy, can make you lose feeling in your feet, which can be dangerous.

“A person with diabetic neuropathy may step on a nail and not realize it for days, because they’ve lost feeling in the feet. Or they may put their foot into a hot bath, but if the water’s scalding hot and they have no feeling, they can develop burns,” Holmes says.

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Delayed detection of wounds or burns can lead to delayed treatment. And delayed treatment raises the risk of infection.

Foot infections can be especially harmful to people with diabetes. Good blood flow helps to heal foot wounds and deliver medications like antibiotics that can help fight infections. But diabetes reduces blood flow to the feet. That can prevent infections from healing.

When infections don’t heal, amputation of a toe, foot, or part of the leg may be needed. Amputation can prevent a deadly infection from spreading to the rest of the body. But amputations are risky and can seriously affect quality of life.

That’s why NIH is funding several research efforts to improve the treatment of diabetic foot problems and reduce the need for amputations. “Research teams are looking for better ways to heal foot wounds, open up blood flow, and fight infections,” Armstrong says.

If the Shoe Fits

No matter your age or health conditions, wearing well-fitting, supportive shoes can have a big effect on your health. But research suggests that many of us wear shoes that are the wrong size or ill-fitting.

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“Our foot tends to widen a bit as we get older, and it can also widen during pregnancy,” Wu says. “So if your foot size was measured at age 20, it probably won’t be the same years later.”

Feet also tend to gradually widen as the day goes on. “So we often recommend that if you’re shopping for new shoes, go in the afternoon or evening when your feet are a little bigger,” Wu says.

If your feet haven’t been measured in a while, consider doing so. A foot-measuring device, called a Brannock Device, can measure both the length and width of your feet. It’s usually available at shoe stores.

Experts suggest leaving a little space at the front of the shoe, because when we walk, our feet tend to shift forward.

“I’ve seen a lot of patients who end up losing a toenail, or it turns black, because the front of the shoe doesn’t have enough room,” Wu says.

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Make sure that the shoes are comfortable from the start. “If they don’t feel right, don’t think that you can break them in later. That could cause blisters and pain,” Holmes says. “Pain is meant to be a cardinal sign to tell you that something is wrong. When you don’t listen to it, you get in trouble.”

Any time you have foot pain that lingers, it’s a good idea to see a health care provider. Give your feet the attention they deserve.

“I suggest to my patients that when you go to your doctor, and you take your clothes off for the exam, make sure you take off your shoes and your socks too. Have the doctor take a look at your feet,” Holmes says. “I think that’s important, to catch foot problems sooner than later.”

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Adenoiditis: Causes, who is at risk, signs and symptoms, diagnosis, treatment | Health

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Adenoiditis is a type of health condition wherein the adenoids (tissue behind the nose and above the throat) gets inflamed and it is common among children and leads to problems like snoring, mouth breathing, recurrent ear infections, decreased hearing, difficulty in breathing, cracked lips, runny nose and bad breath. Adenoiditis occurs when there is inflammation of the adenoid tissue resulting from infection, allergies or irritation from stomach acid as a component of laryngopharyngeal reflux (LPR).

Adenoiditis: Causes, who is at risk, signs and symptoms, diagnosis, side effects, treatment (Photo by Twitter/DrMary_Alphonse)
Adenoiditis: Causes, who is at risk, signs and symptoms, diagnosis, side effects, treatment (Photo by Twitter/DrMary_Alphonse)

In an interview with HT Lifestyle, Dr Nitty Mathew, Senior Specialist – ENT at Aster CMI Hospital, revealed, “Adenoiditis is usually caused by an infection of adenoids. Adenoids become apparent by 2 years of age and regress in size after 8 years. If these remain swollen for a prolonged time, then they can become problematic.”

Highlighting who is at risk of developing adenoiditis, she shared that since adenoids usually shrink by adulthood, children are most susceptible to its infection. They can be more prone to developing adenoiditis if the child is

● Bottle fed

● Breast fed in lying down position

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● Have an infection near the nose or throat

● Suffering from an allergy

According to her, the symptoms of adenoiditis include:

● Stuffy and blocked nose

● Snoring

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● Sleep apnea

● Cracked lips, dry mouth

● Glue ear

● Ear pain and infections

● Swollen neck glands

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She said, “To diagnose adenoiditis, your doctor will conduct a check-up of your child’s nose, ears, mouth and throat. In case the symptoms are worse, your doctor may also suggest he/she undergo an X-ray to see degree of enlargement of adenoids and obstruction of nasal airway.”

Talking about the side effects of adenoiditis, Dr Nitty Mathew pointed out that the complications of untreated adenoiditis include –

● Runny nose

● Recurrent ear infections, decreased hearing

● Dry mouth, Dental caries

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● Speaking with a nasal tone

● Adenoid facies

The health expert added, “Adenoid facies is defined as the open -mouthed appearance in children, associated with a narrow nose, shortened upper lip, narrow palate, high palatal vault and dental crowding.” She concluded, “Usually by 8years of age adenoids regress, but keeping good hygiene can prevent repeated infections. Mild symptoms warrants only supportive treatment, but if your doctor suspects any bacterial infection then the child will have to be treated with antibiotics and then kept on nasal sprays to decrease the size of adenoids. In case the medications are not bringing intended relief of symptoms, then a surgery called adenoidectomy to remove the enlarged adenoids will have to be done.”

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Researchers explain: What causes long Covid breathing problems

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Researchers at Stanford University have found that people are experiencing breathing problems post Covid-19 due to a condition known as lung fibrosis in which the damaged lungs form scar tissue, that makes it difficult for the lungs to expand and contract.

The research showed that overactivity of genes that regulate inflammation and immune responses leads to lung fibrosis.

Long Covid cases can be severely debilitating and resistant to treatment, said Gerlinde Wernig, Assistant Professor of pathology, at Stanford University.

What`s worse, lung function can continue to decline, even without a new Covid-19 infection, Wernig said.

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The finding published in the Proceedings of the National Academy of Sciences offers hope that, one day, targeted drugs could intervene to quell the genes behind the damage.

In the study, the team started by looking at lung tissue samples from five Covid-19 patients who had symptoms of the disease — such as shortness of breath — for one or more months. The lungs of people who had symptoms after infection with SARS-CoV-2 looked like the lungs of people with end-stage pulmonary fibrosis.

By analysing single cells from the patients` tissue samples, the scientists also saw similarities in the pattern of RNA production — which can hint a cell`s overall function — between samples of tissue from long Covid patients and samples from patients with pulmonary fibrosis.

“We saw this same pattern across all human Covid lung samples,” Wernig said.

As with other lung infections, the initial Covid-19 infection in the lungs kicked off an inflammatory process. In the case of long-Covid patients, however, the immune dysfunction keeps going long after the virus is gone — similar to what happens in chronic pulmonary fibrosis.

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To test whether lung fibrosis could be firmly connected to Covid infections, they looked at lung fibrosis in mice infected with a SARS-CoV-2-like virus and found significant increases in fibrosis and immune dysfunction.

“Innate immune cells go crazy after that infection,” Wernig said, referring to the part of the immune system that forms the first line of defence against pathogens.

In a mouse model engineered to more closely represent human biology, researchers showed that, when the mice contracted SARS-CoV-2, scarring in the lung tissues shot up, as did levels of immune cells interleukin-6, CD47 and pJUN. There was also a bright side to these experiments.

“When we did the same experiments but blocked CD47 and Il-6, we saw very little fibrosis,” Wernig said. “This hints at possible treatments for long Covid involving drugs that carry out targeted immune blockades.”

Also Read: Mumbai: All wards have Covid-19 cases; only one critical

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89Bio’s NASH drug meets main goals of mid-stage study, Health News, ET HealthWorld

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89Bio's NASH drug meets main goals of mid-stage study

New Delhi: Drug developer 89Bio Inc said on Wednesday its treatment for a liver disease called non-alcoholic steatohepatitis met the main goals of a mid-stage trial, sending its shares up 50 per cent in premarket trading.

The company’s experimental drug, Pegozafermin, demonstrated at least one-stage fibrosis improvement without worsening of NASH and NASH resolution without worsening of fibrosis in both trial doses.

89Bio said the data supports advancement to late-stage development.

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