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Mediterranean diets may keep prostate cancer and Alzheimer’s at bay

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Scientists have come forth with findings that report the importance of Mediterranean diets, or diets rich in vegetables and fruits with fish, in keeping serious diseases such as prostrate cancer and Alzheimer’s disease at bay.

Mediterranean diet is primarily a plant-based eating plan that includes a daily intake of whole grains, olive oil, fruits, vegetables, beans and other legumes, nuts, herbs, and spices.

Other foods like animal proteins are eaten in smaller quantities, with the preferred animal protein being fish and seafood.

A study, published in the journal Neurology, has found that people who consume MIND and Mediterranean diets may have fewer signs of Alzheimer’s disease – amyloid plaques and tau tangles in their brain – than people who do not consume such diets.

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While they are both similar diets, the MIND diet prioritizes green leafy vegetables like spinach, kale and collard greens along with other vegetables.

While this study exhibits an association of a regular consumption of such diets with fewer Alzheimer’s disease plaques and tangles, it does not establish a causative relationship.

“These results are exciting – improvement in people’s diets in just one area – such as eating more than six servings of green leafy vegetables per week, or not eating fried foods – was associated with fewer amyloid plaques in the brain similar to being about four years younger,” said study author Puja Agarwal of RUSH University in Chicago, US.

The study involved 581 people with an average age of 84 at the time of diet assessment who agreed to donate their brains at death to advance research on dementia.

Participants completed annual questionnaires asking how much they ate of food items in various categories.

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The participants died an average of seven years after the start of the study.

Right before death, the study found that 39 per cent of participants had been diagnosed with dementia.

When examined after death, 66 per cent met the criteria for Alzheimer’s disease, the study said.

At autopsy, the researchers examined participants’ brains to determine the amounts of amyloid plaques and tau tangles.

The researchers then surveyed the questionnaires regarding their diets collected over the follow-up period and rated the quality of the diet followed by each person.

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When looking at single diet components, the researchers found people who ate the highest amounts of green leafy vegetables, or seven or more servings per week, had plaque amounts in their brains corresponding to being almost 19 years younger than people who ate the fewest, with one or fewer servings per week.

“Our finding that eating more green leafy vegetables is in itself associated with fewer signs of Alzheimer’s disease in the brain is intriguing enough for people to consider adding more of these vegetables to their diet,” said Agarwal.

“Future studies are needed to establish our findings further,” said Agarwal.

A limitation of the study was that participants were mostly white, non-Hispanic, and older so the results cannot be generalized to other populations.

Another research by University of South Australia, Australia, has found that men who consume colourful fruits and vegetables on a regular basis are less likely to be diagnosed with prostate cancer (PC). The study is published in the journal Cancers.

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A rainbow of foods rich in certain micronutrients helps to prevent PC as well as speed up recovery among men who undergo radiation treatment for the disease, the study said.

The findings highlighted the importance of a Mediterranean or Asian diet that includes these foods.

Researchers in this study compared micronutrient plasma concentrations of prostate cancer patients with a healthy control group, revealing low levels of lutein, lycopene, alpha-carotene, and selenium in PC patients and high levels of iron, sulphur, and calcium in the same group, relative to controls.

Increased DNA damage after radiation exposure was also associated with low lycopene and selenium in blood plasma, the study said.

Men with plasma concentrations lower than 0.25 micrograms (ug) per millilitre (mL) for lycopene and/or lower than 120ug/L for selenium have an increased risk of prostate cancer and are likely to be more sensitive to the damaging effects of radiation, the study found.

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Foods that are rich in lycopene include tomatoes, melons, papayas, grapes, peaches, watermelons, and cranberries. Selenium-rich foods include white meat, fish, shellfish, eggs, and nuts.

Prostate cancer remains one of the most common and fatal cancers in men, but the nutritional deficiencies associated with it remain largely unknown, hence this study, it said.

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Adenoiditis: Causes, who is at risk, signs and symptoms, diagnosis, treatment | Health

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Adenoiditis is a type of health condition wherein the adenoids (tissue behind the nose and above the throat) gets inflamed and it is common among children and leads to problems like snoring, mouth breathing, recurrent ear infections, decreased hearing, difficulty in breathing, cracked lips, runny nose and bad breath. Adenoiditis occurs when there is inflammation of the adenoid tissue resulting from infection, allergies or irritation from stomach acid as a component of laryngopharyngeal reflux (LPR).

Adenoiditis: Causes, who is at risk, signs and symptoms, diagnosis, side effects, treatment (Photo by Twitter/DrMary_Alphonse)
Adenoiditis: Causes, who is at risk, signs and symptoms, diagnosis, side effects, treatment (Photo by Twitter/DrMary_Alphonse)

In an interview with HT Lifestyle, Dr Nitty Mathew, Senior Specialist – ENT at Aster CMI Hospital, revealed, “Adenoiditis is usually caused by an infection of adenoids. Adenoids become apparent by 2 years of age and regress in size after 8 years. If these remain swollen for a prolonged time, then they can become problematic.”

Highlighting who is at risk of developing adenoiditis, she shared that since adenoids usually shrink by adulthood, children are most susceptible to its infection. They can be more prone to developing adenoiditis if the child is

● Bottle fed

● Breast fed in lying down position

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● Have an infection near the nose or throat

● Suffering from an allergy

According to her, the symptoms of adenoiditis include:

● Stuffy and blocked nose

● Snoring

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● Sleep apnea

● Cracked lips, dry mouth

● Glue ear

● Ear pain and infections

● Swollen neck glands

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She said, “To diagnose adenoiditis, your doctor will conduct a check-up of your child’s nose, ears, mouth and throat. In case the symptoms are worse, your doctor may also suggest he/she undergo an X-ray to see degree of enlargement of adenoids and obstruction of nasal airway.”

Talking about the side effects of adenoiditis, Dr Nitty Mathew pointed out that the complications of untreated adenoiditis include –

● Runny nose

● Recurrent ear infections, decreased hearing

● Dry mouth, Dental caries

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● Speaking with a nasal tone

● Adenoid facies

The health expert added, “Adenoid facies is defined as the open -mouthed appearance in children, associated with a narrow nose, shortened upper lip, narrow palate, high palatal vault and dental crowding.” She concluded, “Usually by 8years of age adenoids regress, but keeping good hygiene can prevent repeated infections. Mild symptoms warrants only supportive treatment, but if your doctor suspects any bacterial infection then the child will have to be treated with antibiotics and then kept on nasal sprays to decrease the size of adenoids. In case the medications are not bringing intended relief of symptoms, then a surgery called adenoidectomy to remove the enlarged adenoids will have to be done.”

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Researchers explain: What causes long Covid breathing problems

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Researchers at Stanford University have found that people are experiencing breathing problems post Covid-19 due to a condition known as lung fibrosis in which the damaged lungs form scar tissue, that makes it difficult for the lungs to expand and contract.

The research showed that overactivity of genes that regulate inflammation and immune responses leads to lung fibrosis.

Long Covid cases can be severely debilitating and resistant to treatment, said Gerlinde Wernig, Assistant Professor of pathology, at Stanford University.

What`s worse, lung function can continue to decline, even without a new Covid-19 infection, Wernig said.

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The finding published in the Proceedings of the National Academy of Sciences offers hope that, one day, targeted drugs could intervene to quell the genes behind the damage.

In the study, the team started by looking at lung tissue samples from five Covid-19 patients who had symptoms of the disease — such as shortness of breath — for one or more months. The lungs of people who had symptoms after infection with SARS-CoV-2 looked like the lungs of people with end-stage pulmonary fibrosis.

By analysing single cells from the patients` tissue samples, the scientists also saw similarities in the pattern of RNA production — which can hint a cell`s overall function — between samples of tissue from long Covid patients and samples from patients with pulmonary fibrosis.

“We saw this same pattern across all human Covid lung samples,” Wernig said.

As with other lung infections, the initial Covid-19 infection in the lungs kicked off an inflammatory process. In the case of long-Covid patients, however, the immune dysfunction keeps going long after the virus is gone — similar to what happens in chronic pulmonary fibrosis.

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To test whether lung fibrosis could be firmly connected to Covid infections, they looked at lung fibrosis in mice infected with a SARS-CoV-2-like virus and found significant increases in fibrosis and immune dysfunction.

“Innate immune cells go crazy after that infection,” Wernig said, referring to the part of the immune system that forms the first line of defence against pathogens.

In a mouse model engineered to more closely represent human biology, researchers showed that, when the mice contracted SARS-CoV-2, scarring in the lung tissues shot up, as did levels of immune cells interleukin-6, CD47 and pJUN. There was also a bright side to these experiments.

“When we did the same experiments but blocked CD47 and Il-6, we saw very little fibrosis,” Wernig said. “This hints at possible treatments for long Covid involving drugs that carry out targeted immune blockades.”

Also Read: Mumbai: All wards have Covid-19 cases; only one critical

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89Bio’s NASH drug meets main goals of mid-stage study, Health News, ET HealthWorld

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89Bio's NASH drug meets main goals of mid-stage study

New Delhi: Drug developer 89Bio Inc said on Wednesday its treatment for a liver disease called non-alcoholic steatohepatitis met the main goals of a mid-stage trial, sending its shares up 50 per cent in premarket trading.

The company’s experimental drug, Pegozafermin, demonstrated at least one-stage fibrosis improvement without worsening of NASH and NASH resolution without worsening of fibrosis in both trial doses.

89Bio said the data supports advancement to late-stage development.

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