Connect with us

Health

Study suggests how nucleolar DNA damage response to cancer treatment, Health News, ET HealthWorld

Published

on

Study suggests how nucleolar DNA damage response to cancer treatment

North Carolina: Proteins are required for cancer to spread throughout the body, which affects millions of people each year. Scientists are sabotaging the disease’s protein factories in an attempt to defeat it.

Researchers from the University of North Carolina at Charlotte encapsulated the young field of nucleolar DNA damage response (DDR) pathways in a new forum paper published in Trends in Biology. The review focuses on six mechanisms by which cells repair DNA damage, one of which was published in Nucleic Acids Research five months ago by the same authors. Future applied researchers will be able to stymie cancer reproduction and growth by attacking these mechanisms.

“The whole purpose of the Trends paper is to bring attention to scientists in the field and trigger their research,” said Shan Yan, the main author. “I did not realize the significance of this field, which is only fifteen years old, until a couple of years ago.”

In a groundbreaking 2007 paper published in Nature, researchers began the field by unveiling the first pathway within the nucleolus, an area within an organelle, or room, within the cell. Inside the nucleolus, different molecules help copy DNA, which contains the plans for cells. Different factors can cause glitches, such as strand breaks, in the copies. These researchers found a way to help heal glitches when copying ribosomal DNA, or the plans for the protein factories of the cell.

By studying these mechanisms, researchers can target cancer, which relies on ribosomal DNA to make the proteins they need to attack the human body. For instance, a Phase I clinical trial is already underway for a drug that targets the second mechanism listed in the paper if the cancer cells can’t heal glitches, then they can’t make new factories and hence can’t make new proteins.

Advertisement

While the first four mechanisms take place inside the nucleolus, which is in a room cordoned off within the watery cell, the last two mechanisms use a new cellular process which won the 2023 Breakthrough Prize in Life Sciences. In the process, called liquid-liquid phase transition, proteins pop up their own liquid ‘tents’ to do their work instead of staying inside a room.

Before working on the nucleolar DDR, Yan researched a protein called APE1. When he discovered that APE1 could locate the nucleolus within a cell and could also pop up these liquid tents to do work, it launched his investigation into these pathways and ultimately to the review paper.

“What’s new is that APE1 acts like a GPS or a first responder,” Yan said. “It says there’s a problem here, we need a police car, a medic, and others to come and be concentrated here.”

Basic researchers like Yan will continue to better define these mechanisms, while more applied scientists can then use those mechanisms as points of attack in the war on cancer.

“This is an exciting and emerging area,” Yan said. “By testing this idea, and if the clinical trial is successful, then these mechanisms will be tickets into new clinical trials and treatments.”

Advertisement

Health

Health 360° Partners With Ap In Healthcare, Health News, ET HealthWorld

Published

on

By

Health 360° partners with AP in healthcare

Visakhapatnam: Health 360°, the healthcare division of Australia-based humanitarian group of companies Global 360°, has signed an investment agreement with public entity Andhra Pradesh Medtech Zone Limited (AMTZ). The strategic partnership will help build and develop healthcare facilities in Vizag which will be equipped with world-class facilities and life-saving medical equipment, to be provided by AMTZ.

The first in a series of healthcare projects in the pipeline is a 200-bed greenfield hospital built in two stages with each stage having 100 beds. It is scheduled for completion in mid-2023. The hospital will provide a wide and diverse range of medical specialties and procedures. Health 360° CEO, Dr Guru Yajaman, said: “We are honoured to have AMTZ onboard for this collaboration as we see a valued partner in them. They are one of the leading medical technology manufacturers in the world. This is a massive initiative that is very close to our hearts and consistent with our mission to deliver seamless healthcare experience to the people of India.”

Dr Jitendra Sharma, MD and CEO of AMTZ, said: “We are thrilled to announce that AMTZ is committed to working with Health 360° to revolutionise the healthcare industry. This partnership marks the beginning of a new era in the democratisation of medical technology. This would be the first hospital in India to be operated using only ‘Made in India’ medical equipment.”

Follow and connect with us on , Facebook, Linkedin, Youtube

Advertisement

Continue Reading

Health

C3 Introduces Innovative Menstrual Hygiene Kit to Empower Young School Girls, Health News, ET HealthWorld

Published

on

By

C3 Introduces Innovative Menstrual Hygiene Kit to Empower Young School Girls

Pataudi, Haryana: To help young girls navigate puberty – which is often a time of significant physical and emotional upheaval – C3 has been working in five schools of Pataudi district, Haryana. The initiative is supported by Open Text, and has been equipping over 1000 adolescent girls with life skills, digital and financial literacy, and information on menstrual health and hygiene.

C3 introduced an unique, first-of-its-kind resource – Navya Kits – to the girls under this intervention. A collection of products and information that would help these young girls understand and manage their periods and dispel myths and taboos surrounding menstruation, these Navya Kits are a cornerstone for adolescent menstrual hygiene. The kits contain six reusable pads (that would last up to 2 years), a hot water bottle for menstrual pain management, a diary with interactive information on menstrual hygiene and taboos, and a detergent bottle that will help the girls wash and re-use their pads. To further supplement wider usage and safe disposal of sanitary napkins, C3 has also begun setting up incinerators in all of the five schools in which the initiative has been running.The Navya kits are also an essential tool for future advocacy around menstrual hygiene, and is something C3 will aim to disseminate through its other adolescent health initiatives as well.

At the launch event, Vandana Nair, Lead, Adolescent and Young People Program at C3, further emphasized the importance of educating young girls about menstrual hygiene, stating that “Menstruation is a natural bodily process that they will likely experience for several decades. By providing them with accurate information and resources, we can help them understand and manage their menstrual cycle and dispel any myths or taboos surrounding menstruation.”

Dr Tanaya Narendra, popularly known as Dr Cuterus, an Instagram influencer with over a million followers and author, was also present at the launch, and interacted directly with the young girls to answer their pressing concerns, to encourage them to have open conversations around menstruation, and providing valuable insights on how young girls can maintain their menstrual health. According to Dr. Cuterus, “this initiative by Centre for Catalyzing Change (C3) is absolutely unique, fun, and important for all the adolescent girls between the ages of 11-13. The products in the Navya kit will help young girls be prepared for their first period and also give them the right information in an engaging manner.

Ms. Pushpanjali Saikia, CSR Lead India from Micro Focus now Open Text, reasserted the need to provide girls with all the necessary information to help them achieve both better health and future success. This includes digital literacy, larger emotional and physical wellbeing, and the confidence to seek out better opportunities and better life choices in today’s increasingly digitized world.

Advertisement

Continue Reading

Health

Every disease has a non-biomedical component; these societal aspects merit consideration as well:Shalini Bharat, Director & VC, Tata Institute of Social Sciences, Mumbai

Published

on

By

Every disease has a non-biomedical component; these societal aspects merit consideration as well:Shalini Bharat, Director & VC, Tata Institute of Social Sciences, Mumbai

Shahid Akhter, editor, ETHealthworld, spoke to Shalini Bharat, Director and Vice Chancellor, Tata Institute of Social Sciences, Mumbai, to figure out the non-biomedical determinants and identify vulnerabilities underlying health issues.

Collaboration and partnership in healthcare
If you remember, SDG 17 (Sustainable Development Goal) is about collaborations and partnerships, and I think in healthcare, more than anywhere else, collaborations and partnerships matter. Today, all of us probably complement each other’s characteristics or competencies, and the problems are so unique and complex that one size does not fit all. Similarly, one solution also will not bring the kind of results desired. and therefore, we need to build multiple partners onto the same platform. The other issue that requires us to bring a partner is that we have recognised that most issues, including all diseases, have not just a biomedical side to them but also a non-biomedical side to them, which means that we bring social dimensions. These are interdisciplinary and multidisciplinary focuses, along with a medical approach. We need to work in teams. I think it is very important and critical to work in multidisciplinary teams and to work in a collaborative way.

Need for social counselling in healthcare
If we look at the TB issue, we recognise today that, despite treatment being available, we have not been able to control TB as a problem in the country. In fact, India has almost one-fourth of the world’s TB burden. and that is because in the last several years we have only seen this as a bio-medical problem. Now, increasingly, we have realised that we need to understand that people had multiple issues before they had TB or as a result of TB. They have this problem, but they also lose employment at times, they fall into the poverty bracket, there is a huge stigma around the disease, and then there is the gender dimension: men have different consequences, but women have and face different consequences. There is a great deal of need for counselling to be done here. And counselling is not just about taking care of psychosocial issues but also linking them to health services, other government schemes, and so on. And all this requires that we work alongside biomedical providers. But then there are those that can provide psychosocial care; we also need to bring in community leaders; we also need to bring in peer members, that is, those who have survived TB, and they become champions and provide peer-based counselling. So this is one great example, and this is now happening in India.

Collaboration in TB care
From our own example, we know that, as an academic institution, we are providing support to the government, that is, the Central TB Division, in the form of providing trained psycho-social counsellors, providing training for them, and being able to look at drug-resistant TB as one of the issues. In four states, we are providing psychosocial care and counselling to drug-resistant TB cases. In addition to that, we are also finding that public-private providers are also collaborating in TB care.

Tata Inst. of Social Sciences
The Tata Institute of Social Sciences is a community-engaged university and India’s premier social science university. We have four campuses: Mumbai, Hyderabad, Tuljapur, which is a rural campus, and Guhati, in the northeast. This institute started as an institute for the professional training of social workers, but in the last several years we have grown to more than 50 PG programmes, four robust UG programmes, and 18 PhD programmes. And I think this is one of the only universities that has applied social science as its focus, and we have almost seven thousand students at this point in time, along with a school of vocational education. So a very multi-disciplinary social science university

Advertisement

Continue Reading

Trending